I received dose #2 yesterday. For the record, I experienced a headache overnight and have been fatigued for most of the day. That's "more dependent on coffee than usual" fatigue, though, not "stay home from work" fatigue. However, after comparing notes with my colleagues there have been a pretty wide range of reactions, from *nothing* to whole-body soreness + shortness of breath, so don't expect my experience to be predictive.