The most famous one is, perhaps, the home win over Edmonton in 1982 that confirmed that the run & shoot was for real and that the Argos had escaped the doldrums of the 70's. Anyone else recall any impactful regular season games that turned the season around (one way or the other)?

I'll start with the October 2012 game against Saskatchewan. IIRC, people were down on the Argos at the time because (i) it was perceived that Ray hadn't been playing well and (ii) the Argos had just lost to a bad Winnipeg team by a score of 44-32 o something like that. The Argos held off Saskatchewan and clinched a playoff spot and they wouldn't love the rest of the year culminating in the 100th Grey Cup win.